Standard 4: determining adequate sample sizes.

نویسندگان

  • Ingeborg van der Tweel
  • Lisa Askie
  • Ben Vandermeer
  • Susan Ellenberg
  • Ricardo M Fernandes
  • Haroon Saloojee
  • Dirk Bassler
  • Douglas G Altman
  • Martin Offringa
  • Johanna H van der Lee
چکیده

There are many challenges to be faced when conducting randomized controlled trials (RCTs) in pediatric research. One important challenge is the determination of an appropriate sample size. Recruiting more children than necessary risks unnecessary overexposure of children to an inferior treatment, whereas underestimating the sample required will lead to inconclusive or unreliable results. Both options pose important ethical dilemmas for the pediatric researcher.

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عنوان ژورنال:
  • Pediatrics

دوره 129 Suppl 3  شماره 

صفحات  -

تاریخ انتشار 2012